Newman TB, Hulley SB "Carcinogenicity of lipid-lowering drugs. If you are pregnant or breastfeeding, do not take Zetia while taking a statin. Whitfield LR, Porcari AR, Alvey C, Abel R, Bullen W, Hartman D. Effect of gemfibrozil and fenofibrate on the pharmacokinetics of atorvastatin. canada zithromax indication zithromax
This complaint affected about 1 in 20 of the population in the trials, irrespective of therapy. These plaques block the arteries and reduce the flow of blood to the tissues the arteries supply. When plaques rupture, a forms on the plaque, thereby further blocking the artery and reducing the flow of blood. Do not use this medication more often than prescribed or continue to use it for longer than 10 days. Such patients merit closer monitoring.
Women who are pregnant or may become pregnant. Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development. Because HMG-CoA reductase inhibitors statins decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, Zocor may cause fetal harm when administered to a pregnant woman. Atherosclerosis is a chronic process and the discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. There are no adequate and well-controlled studies of use with Zocor during pregnancy; however, in rare reports congenital anomalies were observed following intrauterine exposure to statins. In rat and rabbit animal reproduction studies, simvastatin revealed no evidence of teratogenicity. Zocor should be administered to women of childbearing age only when such patients are highly unlikely to conceive.
This medication may not be approved by the FDA for the treatment of this condition. FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not take simvastatin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking simvastatin. Can my hair recover somehow? provera
Told her about it and she still wanted me to get back on the drug if my cholesterol was elevated. I told her I would not put this poison back in my body and that my side effects greatly outweighed any benefit this drug may have. It's not fit for human consumption! It is a shame that the ASTEROID and METEOR studies involving Crestor, which were also imaging studies but showed a decrease in the plaque burden in the heart arteriesASTEROID and a regression in some patients and no progression in othersMETEOR of the same thing that was measured in the ENHANCE study CIMT or Carotid Intimal Medial Thickness and generated all the confusion, were not mentioned in the media. The point is that all of these studies are imaging studies and there is no outcome data so I really do not know what any of them mean in a practical sense. Do not share this medication with others. Guymer RH, Baird PN, Varsamidis M, Busija L, Dimitrov PN, Aung KZ, Makeyeva GA, Richardson AJ, Lim L, Robman LD 2013. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Treatment with Zocor produced significant relative risk reductions for all components of the composite endpoints. If, however, a patient who is currently tolerating the 80-mg dose of ZOCOR needs to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin, that patient should be switched to an alternative statin with less potential for the drug-drug interaction. Patients should be advised of the increased risk of myopathy, including rhabdomyolysis, and to report promptly any unexplained muscle pain, tenderness or weakness. If symptoms occur, treatment should be discontinued immediately. What are the possible side effects of Zetia? Zocor simvastatin US prescribing information. Our Zocor simvastatin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Take this by with or without food as directed by your doctor, usually once daily in the evening.
Lipofen R: 50 mg to 150 mg orally once a day with food. Lofibra R and others: 54 mg to 67 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. If you are a woman of childbearing age, you should use an effective method of birth control to prevent pregnancy while using Zetia added to statin therapy. Phan T, Mcleod JG, Pollard JD, Peiris O, Rohan A, Halpern JP "Peripheral neuropathy associated with simvastatin. It may take up to 4 weeks before you get the full benefit of this drug. All patients recovered without sequelae. Supportive measures should be taken in the event of an overdose. The dialyzability of simvastatin and its metabolites in man is not known at present. Rogers: She should first see an allergist or a dermatologist to find out which ingredients in the hair dye may have caused her reaction. Then, if this ingredient can be eliminated from the product she uses there are many dyes free of contact allergens she may be alright. But she should be extremely careful and apply any new hair colors to a small test area first. Consult your doctor before -feeding. Rogers: No. There is no link with hair loss and consumption of red meats, such as steak. Question: Is it necessary to wash my hair every day? Child-Pugh score 5 to 6 compared to healthy subjects. The mean AUC values for total ezetimibe and ezetimibe were increased approximately 3- to 4-fold and 5- to 6-fold, respectively, in patients with moderate Child-Pugh score 7 to 9 or severe hepatic impairment Child-Pugh score 10 to 15. In a 14-day, multiple-dose study 10 mg daily in patients with moderate hepatic impairment, the mean AUC values for total ezetimibe and ezetimibe were increased approximately 4-fold on Day 1 and Day 14 compared to healthy subjects. American Heart Association Task Force on Practice Guidelines. chloroquine
Studies have demonstrated that treatment with atorvastatin is associated with significant reductions in the risk of cardiovascular endpoints and stroke in various patient populations for both primary and secondary prevention. Vollmer says that statins -- if proven to be of benefit in future studies -- could have several advantages over current multiple sclerosis treatments. Moderate. These medicines may cause some risk when taken together. For primary prevention, atorvastatin treatment was effective in hypertensive patients with normal or mildly elevated cholesterol levels as well as in patients with type II diabetes. Patients had relatively low cholesterol levels at baseline in both trials; however, treatment with this medicine still resulted in significant reductions in cardiovascular outcomes and stroke. Lofibra R and others: 160 mg to 200 mg orally once a day with food. Isabelle Marie, MD, PhD, and colleagues write in the March issue of the journal and Rheumatism. Asymptomatic Myopathy should be used to refer to CK enzyme elevations without any symptoms. AUC after an 80-mg oral dose. Liver carcinomas were significantly increased in high-dose females and mid- and high-dose males with a maximum incidence of 90% in males. The incidence of adenomas of the liver was significantly increased in mid- and high-dose females. Drug treatment also significantly increased the incidence of lung adenomas in mid- and high-dose males and females. Adenomas of the Harderian gland a gland of the eye of rodents were significantly higher in high-dose mice than in controls. Proof of whether statins affect risk of Alzheimer's disease or Parkinson's disease can come only from controlled clinical trials. But as such trials would be extremely lengthy and expensive, Wolozin doubts they will be undertaken.
One must remember that statins have reduced Cardiovascular Morbidity and Mortality by approximately 40%. While there is no definitive clinical evidence of any strategies that can be used to prevent or reduce muscle injury, there is some evidence that may cause a significant reduction in statin-induced pain. Since the response has been variable, the use of coenzyme Q 10 cannot be recommended with any degree of confidence. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Zetia in the treatment of homozygous sitosterolemia. Simvastatin Zocor is a, FDA approved prescription medication that is used along with a proper diet to help lower "bad" cholesterol and fats such as LDL, triglycerides and raise "good" cholesterol HDL in the blood. It belongs to a group of drugs known as "statins. This may temporarily sting or burn your ear for a minute or two when applied. If these effects persist or worsen, notify your doctor or promptly. National Cholesterol Education Program NCEP: Highlights of the Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. HMG-CoA reductase inhibitors, including simvastatin. Simvastatin reduces levels of "bad" cholesterol low-density lipoprotein, or LDL and triglycerides in the blood, while increasing levels of "good" cholesterol high-density lipoprotein, or HDL. Lipitor, Crestor and Zocor. It is not known whether ezetimibe is excreted into human breast milk. In rat studies, exposure to total ezetimibe in nursing pups was up to half of that observed in maternal plasma. Because many drugs are excreted in human milk, caution should be exercised when Zetia is administered to a nursing woman. Zetia should not be used in nursing mothers unless the potential benefit justifies the potential risk to the infant. Do not use it for longer than prescribed. Contact your doctor if you notice new or worsening symptoms. Bad publicity about the potential side effects doesn't help matters since it distracts attention from the beneficial effects of the medications, she said. Strong CYP3A4 inhibitors: Simvastatin, like several other inhibitors of HMG-CoA reductase, is a substrate of CYP3A4. Simvastatin is metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is not expected to affect the plasma concentrations of other drugs metabolized by CYP3A4. Other health problems: Before taking a medicine, be sure your doctor or pharmacist knows about all your health problems. Other health problems may affect your medicine. Or the medicine for one health problem may affect another health problem. We do not know if Zetia can pass to your baby through your milk. Your doctor will discuss with you whether Zetia is right for you. Remember, the most common reason surgery fails to improve symptoms is an incorrect diagnosis. That means, if you still have urinary leakage when you and sneeze after bladder suspension surgery, be sure to tell your doctor. You may have another medical condition causing the problem, and may need additional treatment or tests. buy generic crestor shopping europe
When all patients receiving Zetia with a statin were compared to all those receiving the corresponding statin alone, Zetia significantly lowered total-C, LDL-C, Apo B, non-HDL-C, and TG, and, with the exception of pravastatin, increased HDL-C compared to the statin administered alone. LDL-C reductions induced by Zetia were generally consistent across all statins. Hypersensitivity reactions, including angioedema swelling of the skin and underlying tissues of the head and neck that can be life-threatening and skin rash occur rarely. Nausea, pancreatitis, muscle damage myopathy or rhabdomyolysis and have been reported. Combining drugs to fight high cholesterol. Frequency not reported: Hypospermia, gynecomastia, thyroid function abnormalities, increases in HbA1c and fasting serum glucose levels. Acid maltase deficiency the genetic disorder also referred to as Pompe's Disease has been revealed following simvastatin the active ingredient contained in Zocor therapy in at least one presymptomatic patient. Chinese patients applies to other Asian patients. Ontario residents, researchers in Canada found that the overall odds of developing diabetes were low in patients prescribed statins. Still, people taking Lipitor had a 22 percent higher risk of new-onset diabetes, Crestor users had an 18 percent increased risk and people taking Zocor had a 10 percent increased risk, relative to those taking which appears to have a favorable effect on diabetes.
These results are consistent with Zetia being a potent cholesterol absorption inhibitor. Avoid close physical contact with others such as during an outbreak until the have completely healed. Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with or do not feel sick. Take the medicine out of the refrigerator and allow it to reach room temperature for 30 to 45 minutes before injecting your dose. Do not heat a syringe or injection device. There was no effect on plasma levels. Serious side effects may include muscle breakdown, liver problems, and increased blood sugar levels. Common side effects include constipation, headaches, and nausea. A lower dose may be needed in people with kidney problems. Six months into treatment, the researchers found that the number of brain lesions was reduced by 43%. In addition, the researchers projected that Zocor would decrease the annual rate of relapses from 43% before treatment to 32% after treatment. Frequency not reported: Hypospermia, gynecomastia, thyroid function abnormalities, increases in HbA1c and fasting serum glucose levels. Acid maltase deficiency the genetic disorder also referred to as Pompe's Disease has been revealed following simvastatin therapy in at least one presymptomatic patient. They save lives every day, and they have changed the face of cardiovascular medicine. But sometimes side effects can be a problem or can be serious. If treatment with itraconazole, ketoconazole, posaconazole, voriconazole, erythromycin, clarithromycin or telithromycin is unavoidable, therapy with simvastatin must be suspended during the course of treatment. Gabriella Gosman, MD, assistant professor of ob-gyn and reproductive science at the University of Pittsburgh. ZOCOR should be prescribed with caution in the elderly. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. buy effexor japan
In 11 patients with reductions in LDL-C, the mean LDL-C changes for the 40- and 80-mg doses were 14% range 8% to 23%, median 12% and 30% range 14% to 46%, median 29% respectively. One patient had an increase of 15% in LDL-C. Another patient with absent LDL-C receptor function had an LDL-C reduction of 41% with the 80-mg dose. CoQ10 has been used to treat many different conditions. There's evidence that CoQ10 can lower slightly. Simvastatin is usually taken at bedtime or with an evening meal. If you take simvastatin more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results. Coenzyme Q10 is a nutrient that occurs naturally in the body. CoQ10 is also in many foods we eat. Vollmer envisions that there ought to be enough research completed in about four years for a consensus to emerge about statins' potential role as multiple sclerosis treatments. No specific diagnostic signs were observed in rodents. At these doses the only signs seen in dogs were emesis and mucoid stools. Pharmaceuticals Ltd. United Kingdom GBN. Joel A. Simon, MD, assistant professor of medicine and epidemiology at the University of California, San Francisco. First of all, muscle problems do occur with all statins. Muscle complaints have been documented to increase with increasing blood levels of the statin. There are 2 different classes of statins: Fat soluble and water soluble. American College of Obstetricians and Gynecologists: "Surgery for Stress Urinary Incontinence. Zetia coadministered with fenofibrate significantly lowered total-C, LDL-C, Apo B, and non-HDL-C compared to fenofibrate administered alone. Hypersensitivity to any component of this medication. The risk of myopathy and rhabdomyolysis is increased by high levels of statin activity in plasma. Simvastatin is metabolized by the cytochrome P450 isoform 3A4. Certain drugs which inhibit this metabolic pathway can raise the plasma levels of simvastatin and may increase the risk of myopathy.
National Kidney and Urologic Diseases Information Clearinghouse: "Urinary Incontinence in Women. Always tell your doctor or pharmacist about all the medicines you take. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. That information will help prevent serious problems. ZOCOR, promptly interrupt therapy. If an alternate etiology is not found do not restart ZOCOR. Rogers: Unless you pulled so hard you destroyed the follicle, these hairs should grow back. I would recommend you allow a full 12 months to see the hair return, if it hasn't already. Question: Two weeks ago I fell and got a 4-inch cut on the back of my head. How should I take Aubagio? Ezetimibe is a white, crystalline powder that is freely to very soluble in ethanol, methanol, and acetone and practically insoluble in water. Zocor expired on June 23, 2006. Zetia. There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment. If you have any questions about Zetia, ask your doctor. Only your doctor can determine if Zetia is right for you. How should I take gemfibrozil? imipramine
Padala KP, Padala PR, Potter JF "Simvastatin-induced decline in cognition. MD's. Many of my friends are MD's. But the credentials of MD doesn't mean that they are always making the right choice. Symptomatic Myopathy should be used to refer to muscle pain myalgias weakness, and cramps. Rogers: Topical minoxidil is what you need to be applying to your scalp to help achieve thicker hair and to keep it in the actively growing anagen phase for a longer period of time. You must use if for 6-12 months every day and twice daily in order to see optimal results. Disclaimer: Every effort has been made to ensure that the information provided by Multum, Truven Health Analytics, Inc. Simon adds that it makes sense why estrogen would have this effect, since this hormone changes the of bile in the gallbladder so gallstones are more likely to form.
Due to the possible risk of muscle injury, the FDA now recommends that no new patients should start taking that dose -- 80 milligrams. No microscopic changes were observed in the testes of rats from either study. Simvastatin Oral Suspension should be considered. Women who are breastfeeding should not use Zocor. Patients who have a lipid disorder and are breastfeeding should be advised to discuss the options with their healthcare professional. This medication may also help reduce how long pain remains after the sores heal. While developing and researching lovastatin, Merck scientists synthetically derived a more potent HMG-CoA reductase inhibitor from a fermentation product of A. terreus, which was designated MK-733 later to be named simvastatin. Measure LDL-C levels every 4 to 8 weeks after starting this drug. Rogers: Fish oil supplements may help with certain inflammatory conditions of the skin and scalp, such as psoriasis. However, there is no data linking fish oil consumption with hair health specifically. Question: I pulled some of my hair out about 9 months ago. Will it ever grow back? Ivax Pharmaceuticals unit at all other strengths were given approval by the FDA to manufacture and sell simvastatin as a with 180-day exclusivity. Your care provider will show you the best places on your body to inject Repatha or place the on-body infusor. Use a different place each time you give an injection. Do not inject into the same place two times in a row. Results from the extension at 48 weeks were comparable to those observed in the base study. However, women taking -- the most popular type of cholesterol-lowering drug -- had a 45% drop in the chance they would need gallbladder surgery. That was a very significant finding, he says. Response to therapy depends on the degree of LDL-receptor function. This drug should not be used in patients without familial hypercholesterolemia or atherosclerotic cardio vascular disease. ULN occurred in two 2% individuals in the Zetia coadministered with simvastatin group and in zero individuals in the simvastatin monotherapy group. Jacob SS, Jacob S, Williams C, Deeg MA. Simvastatin, fenofibrate, and rhabdomyolysis. ketoconazole generika shop
Due to the increased risk of myopathy, including rhabdomyolysis, associated with the 80-mg dose of Zocor, patients unable to achieve their LDL-C goal utilizing the 40-mg dose of Zocor should not be titrated to the 80-mg dose, but should be placed on alternative LDL-C-lowering treatments that provides greater LDL-C lowering. What other drugs will affect simvastatin Zocor? Keep all regular medical and laboratory appointments. Lopid gemfibrozil US prescribing information. Pfizer Pharmaceuticals, Ltd. April, 2016. C low-density lipoprotein cholesterol LDL-C apolipoprotein B Apo B and non-high-density lipoprotein cholesterol non-HDL-C in patients with primary heterozygous familial and non-familial hyperlipidemia. Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose. What happens if I overdose? Women of childbearing age should be advised to use an effective method of birth control to prevent pregnancy while using Zetia added to statin therapy. Discuss future pregnancy plans with your patients, and discuss when to stop combination Zetia and statin therapy if they are trying to conceive. Patients should be advised that if they become pregnant they should stop taking combination Zetia and statin therapy and call their healthcare professional. Gemfibrozil is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely. Rhabdomyolysis was rare in the SEARCH study. Avoid drinking alcohol. It may interfere with your treatment.
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice. Statins block the enzyme in the liver that is responsible for making cholesterol. This enzyme is called hydroxy-methylglutaryl-coenzyme A reductase HMG-CoA reductase. Scientifically, statins are referred to as HMG-CoA reductase inhibitors. Tell us on WebMD's Coping with Cholesterol message board. Never take simvastatin in larger amounts, or for longer than recommended by your doctor. Follow your doctor's dosing instructions very carefully. Taking too much of this medication may cause serious or life-threatening side effects. LDL-C value was 124. Butylated hydroxyanisole is added as a preservative. Since fat-soluble statins can easily enter the inside of the muscle cells, theoretically muscle damage should be increased with their use, as water-soluble statins do not easily get into the muscle cells. This hypothesis has not been confirmed and cases of Rhabdomyolysis, while rare, occurring about 1 time for every 15 million prescriptions written, has occurred with all statins. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. HMG-CoA reductase inhibitory activity was increased approximately 45% compared with 18 patients between 18-30 years of age. In 1994, publication of the results of the 4S provided the first unequivocal evidence that lowering LDL cholesterol via statin treatment reduces cardiovascular events and overall mortality. How fast you recover depends on the specific procedure. Open retropubic suspension surgery is done under general anesthesia, and requires a hospital stay. The surgery itself takes about one hour, but discomfort can last 6-8 weeks. Some sling procedures may be done under local anesthesia in an outpatient clinic. In general, recovery times are longer for procedures done through the abdomen, and shorter for those done through the or via laparoscopic incisions. Reduce elevated total-C, LDL-C, and Apo B in boys and postmenarchal girls, 10 to 17 years of age with heterozygous familial hypercholesterolemia after failing an adequate trial of diet therapy. Despite the well-documented benefits of cholesterol-lowering drugs called statins, a new study from Finland shows that diet can still make a difference in patients taking these drugs when it comes to keeping cholesterol under control. Group; Link E; Parish S; Armitage J; Bowman L; Heath S; Matsuda F; Gut I; Lathrop M; Collins R 2008. pdf. N Engl J Med. Though it's often more effective than other multiple sclerosis treatments, its side effects limits it to 5% to 10% of people with multiple sclerosis. If you become pregnant while taking Aubagio or within 2 years after you stop, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of teriflunomide on the baby. geodon capsule price philippines
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All were prescribed statins between 2006 and 2008 -- the most recent time period for which numbers are available. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Is not subject to the Controlled Substances Act. AUC after an 80-mg oral dose. If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. cefpodoxime order now store uk cefpodoxime
It is reversible on stopping statin. The problem exists, however, that frequent inquiries about muscle pain may prompt symptoms in suggestible patients. Based on clinical experience, statin-related myalgias resolve when stopping the medicine. There is insufficient evidence to conclude whether myalgia that persists after stopping the statin is caused by the medications. All patients who are symptomatic on statin therapy should have done as hypothyroidism can exacerbate symptoms. Here are some examples of statins. For each item in the list, the generic name is first, followed by any brand names. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
Multiple-dose studies of ezetimibe given in combination with statins in rats and rabbits during organogenesis result in higher ezetimibe and statin exposures. Reproductive findings occur at lower doses in combination therapy compared to monotherapy. Concomitant administration of strong CYP3A4 inhibitors. All medicines can cause side effects. Many people don't have side effects. And minor side effects sometimes go away after a while. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. esro.info nimotop
Zocor should be prescribed with caution in the elderly. Single-strength: one can of frozen concentrate diluted with 3 cans of water. In a 48-week, controlled study in adolescent boys and girls who were at least 1 year post-menarche, 10-17 years of age 43. Bladder suspension surgery works well to treat stress incontinence in most cases. Success rates for open retropubic suspension surgery range from 85%-90%. But, the effects do not last forever. Symptoms can return over time, usually after five years. Do not consider Communities as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.